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The synthesis of disodium‐3‐amino‐1‐hydroxypropane‐1, 1‐diphosphonate‐1‐ 14 C. (APD· 2Na)
Author(s) -
Magnien Ernest,
Shaikh Mujahid,
Suh John T.,
Jones Howard
Publication year - 1982
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580191005
Subject(s) - chemistry , sodium hydroxide , chlorobenzene , phosphorus trichloride , phosphorus , sodium , calcium hydroxide , nuclear chemistry , medicinal chemistry , radiochemistry , inorganic chemistry , organic chemistry , catalysis
Disodium‐3‐amino‐1‐hydroxy‐1, 1‐diphosphonate‐1‐ 14 C (APD 2Na), a powerful calcium binding agent and potential drug for the treatment of Paget's Disease was synthesized. The reaction was carried out by reacting β‐alanine (1‐ 14 C) with phosphorus acid and phosphorus trichloride in chlorobenzene. Treatment of the resultant APD with two equivalents of sodium hydroxide gave the title compound.