Premium
Preparation of N(1‐ethyl‐2‐pyrrolidyl‐methyl)2‐methoxy‐4‐iodo‐ 125 I‐ 5‐ethyl sulfonyl benzamide: A radioligand for the radioimmunoassay of sulpiride‐related compounds
Author(s) -
Cardoso Maria Teresa,
Pradelles Philippe
Publication year - 1982
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580190914
Subject(s) - chemistry , benzamide , sulfonyl , diazo , radioligand , sulpiride , medicinal chemistry , organic chemistry , antagonist , binding site , receptor , biochemistry , alkyl
We describe the preparation of 125 I labelling with a higher specific radioactivity of N(1‐ethyl ‐2‐pyrrolidyl‐methyl)2‐ methoxy ‐5‐ethyl sulfonyl benzamide, a potent biological analogue for sulpiride. The incorporation of iodine in the molecule was achieved by the substitution of aromatic amino groups via the diazo compound. Binding and immunological parameters of iodinated and tritiated tracers were compared.