Premium
Synthèses D'indoles Et d'Indolizines Marqués Spécifiquement par 13 C dans le Cycle Pentagonal
Author(s) -
Lautie M. F.,
Corval M.
Publication year - 1982
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580190903
Subject(s) - indolizine , chemistry , indole test , medicinal chemistry , bicyclic molecule , stereochemistry
The syntheses of 2‐ 13 C and 3‐ 13 C indoles and indolizines and 1‐ 13 C indolizine are described. They are obtained from 1‐ 13 C bromoacetaldehyde on (2‐pyridyl) ethylacetate for 2‐ 13 C indolizine, and through cyclisations of suitably labelled intermediates:o‐formotoluidide for 2‐ 13 C indole, o,β‐dinitrostyrene for 3‐ 13 C indole, and 3‐(2‐pyridyl)‐1 propanol for 3‐ 13 C and for 1‐ 13 C indolizines. Every position is more than 90% 13 C‐ labelled.