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Synthesis of encainide‐ 13 C hydrochloride from 2‐nitrobenzaldehyde‐ formyl ‐ 13 C
Author(s) -
Johnson Porter C.,
Covington Robert R.
Publication year - 1982
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580190808
Subject(s) - chemistry , hydrochloride , benzamide , medicinal chemistry , stereochemistry , organic chemistry
A tacile synthesis of 2‐nitrobenzaldehyde‐ formyl ‐ 13 C was developed. This compound was converted to the labelled antiarrhythmic agent, encainide‐ 13 C hydrochloride, 4‐methoxy‐ N ‐[2‐[2‐(1‐methyl‐2‐piperidinyl)ethyl‐ 1 ‐ 13 C ]phenyl]benzamide hydrochloride.