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A procedure for the radioiodination of a ganglioside derivative
Author(s) -
Klemm Nancy,
Su SongNan,
Harnacker Barbara,
Jeng Ingming
Publication year - 1982
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580190806
Subject(s) - chemistry , sodium cyanoborohydride , adduct , moiety , residue (chemistry) , derivative (finance) , galactose oxidase , aldehyde , tyramine , iodine , organic chemistry , combinatorial chemistry , galactose , biochemistry , catalysis , financial economics , economics
A procedure for the preparation of a radioiodinated derivative of ganglioside GM 1 has been devised. Carbon 6 of the terminal galactosyl residue of GM 1 was converted to an aldehyde by galactose oxidase. The adduct formed by this oxidation product of GM 1 with tyramine was reduced with sodium cyanoborohydride. The tyramine moiety covalently attached to GM 1 was then labelled by the conventional iodine chloride procedure. The technique described herein is simple and economical for the preparation of a highly radioactive GM 1 derivative.