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18 O‐labeled nucleosides 3. Preparation and mass spectrometric evaluation of 18 O 2 ‐labeled ara‐C and ara‐U
Author(s) -
Schubert Ernst M.,
Schram Karl H.
Publication year - 1982
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580190805
Subject(s) - chemistry , nucleobase , mass spectrometry , chromatography , radiochemistry , biochemistry , dna
A facile method for the preparation of 18 O labeled ara‐C and ara‐U is described. The method provides a means of incorporating 18 O specifically at the 2‐position of the nucleobase. The site and level of label was established using mass spectrometry.