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Preparation of multitritiated arenes
Author(s) -
Cacace Fulvio,
Speranza Maurizio,
Wolf Alfred P.,
Ehrenkaufer Richard
Publication year - 1982
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580190803
Subject(s) - chemistry , propyne , toluene , catalysis , ionic liquid , ion , ring (chemistry) , nuclear chemistry , medicinal chemistry , radiochemistry , organic chemistry
The decay technique, currently applied to the study of ionic processes in gaseous and liquid systems, requires multitritiated precursors to generate labeled daughter ions. The preparation of three such precursors, namely C 6 3 H x H 6−x , C 6 3 H x H 5−x CH 3 , and C 6 H 5 C 3 H 3−x is described. The ring–labeled precursors were obtained from the cyclization of C 2 3 H 2 , and respectively of a C 2 3 H 2 /propyne mixture, carried out at 25°C over a K 2 CrO 4 –promoted silica–alumina catalyst. The side–chain tritiated toluene was prepared by allowing 3 H 2 O and benzotrichloride to react over a Zn mirror at 200°C. Details of the procedures employed for the radiometric and the isotopic analysis of the multilabeled products are reported.