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Synthesis of 14 C‐labelled fluphenazine esters
Author(s) -
Zólyomi G.,
Tóth I.,
Toldy L.
Publication year - 1982
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580190607
Subject(s) - chemistry , fluphenazine , phenothiazine , derivative (finance) , stereochemistry , chemical synthesis , pharmacology , biochemistry , haloperidol , medicine , neuroscience , financial economics , dopamine , economics , biology , in vitro
Fluphenazine labelled with 14 C at the 3‐propyl position was prepared. Starting from K 14 CN, 3‐chloropropyl p‐toluenesulfonate ( 7 ) was synthesized via 3‐chloropropionic acid ( 4 ) intermediate and coupled with 2‐trifluoromethylphenothiazine. The phenothiazine derivative ( 8 ) obtained was converted into 1a , from which various long acting esters ( 1b , 1c , 1d ) of labelled fluphenazine were prepared for comparative pharmacokinetic studies.