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Rapid tritium labelling of steroids using ethylaluminium chloride and boron tribromide catalysts
Author(s) -
Brooks Ruth A.,
Long Mervyn A.,
Garnett John L.
Publication year - 1982
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580190506
Subject(s) - chemistry , labelling , tritium , radiochemistry , chloride , catalysis , solvent , inert , boron , tribromide , specific activity , inorganic chemistry , organic chemistry , biochemistry , physics , nuclear physics , enzyme
A representative group of steroids have been labelled by exchange using ethylaluminium chloride and boron tribromide as catalyst and a trace of high specific activity tritiated water as isotope source. Careful choice of experimental conditions and a solvent inert to this exchange system ensures the production of high specific activity steroids with high radiochemical purity.