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Synthesis and purification of methyl‐ 13 C fluoride
Author(s) -
Cohen Isaac,
Shulman Jan,
Popowicz Anthony,
Ishida Takanobu
Publication year - 1982
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580190503
Subject(s) - chemistry , methanol , fluoride , yield (engineering) , chloride , impurity , silica gel , nuclear chemistry , carbon dioxide , chromatography , gas chromatography , specific activity , organic chemistry , inorganic chemistry , enzyme , materials science , metallurgy
A 20 mmole quantity of methyl‐ 13 C fluoride at a 13 C‐enrichment level of 90% was prepared by a two‐step synthesis starting with methanol‐ 13 C. The overall yield was 60% of methanol used. A series of gas‐chromatographic treatments using Ascarite, silica gel, and Chromosorb‐102 columns yielded a highly purified methyl fluoride in which the major impurities were less than 10 parts per million of carbon dioxide and 10 parts per million of methyl chloride.