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An improved synthesis of methyl propiolate‐1,2,3‐ 13 c 3
Author(s) -
Lieberman Daniel F.,
Yuan SunShine
Publication year - 1982
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580190415
Subject(s) - chemistry , yield (engineering) , lithium (medication) , chemical synthesis , medicinal chemistry , stereochemistry , in vitro , medicine , materials science , metallurgy , endocrinology , biochemistry
Abstract An high yield synthesis of the title compound from 13 CO 2 is described. A key to the success is direct formation of the ester from the intermediate lithium propiolate‐ 13 C 3 .