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Preparation of tritium labelled synthanecine a and its bis‐N‐ethylcarbamate
Author(s) -
Mattocks A. Robin
Publication year - 1982
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580190403
Subject(s) - chemistry , pyrrolizidine , tritium , carbamate , pyrrolizidine alkaloid , tritium illumination , alcohol , alkaloid , side chain , stereochemistry , organic chemistry , radiochemistry , physics , nuclear physics , polymer
A procedure is described for incorporating tritium into the 3‐CH 2 side chain of synthanecine A, and preparing the carbamate, 2,3‐bis‐N‐ethylcarbamoyloxymethyl‐l‐methyl‐3‐pyrroline, a hepatotoxic pyrrolizidine alkaloid analogue. The pyrrolizidine amino alcohol, retronecine, can be tritium labelled in a similar way.