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Synthesis of 2‐bromo‐[1‐ 14 C]ethanamine hydrobromide
Author(s) -
Bach Peter H.,
Bridges James W.
Publication year - 1982
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580190315
Subject(s) - hydrobromide , chemistry , sublimation (psychology) , yield (engineering) , amine gas treating , hydrochloride , medicinal chemistry , nuclear chemistry , organic chemistry , psychology , materials science , metallurgy , psychotherapist
2‐Bromo‐[1‐ 14 C]ethanamine hydrobromide (BEA) was synthesized from [2‐ 14 C]ethan‐1‐01‐2‐amine hydrochloride, by reaction with HBr in a specially designed chamber at an elevated temperature. The synthetic product was purified in the reaction chamber by fractional vacuum sublimation to give a yield of up to 90% of BEA having a purity greater than 95%.