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Economical syntheses of 3 H‐ 2 H and 14 C‐labeled ethyl acetates
Author(s) -
Alvarez Francisco J.,
Kovach Ildiko M.,
Schowen Richard L.
Publication year - 1982
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580190310
Subject(s) - chemistry , acetic acid , yield (engineering) , tritium , deuterium , ethanol , ethyl acetate , specific activity , radiochemistry , organic chemistry , nuclear chemistry , enzyme , materials science , physics , quantum mechanics , nuclear physics , metallurgy
Tritium and 14 C‐labeled isomers of ethyl acetate are excellent substrates for competitive dual‐labeled radioactive isotopic measurements of β‐deuterium and β‐tritium isotope effects. Methods are given for preparation of the ethyl esters of acetic acid‐2‐ 3 H, acetic acid‐2‐ 14 C, and acetic acid‐2,2‐2H 2 ‐2‐ 3 H, and of the acetic acid ester of ethanol‐l‐ 14 C from the least costly labeled precursors in high purity (yield 70‐80%) on the mmole scale.