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Synthesis of phenyl [1‐ 14 C]acetylene and 1,4–diphenyl[1,4‐ 14 C 2 ] butadiyne
Author(s) -
Dhawan Som N.,
Kagan Jacques
Publication year - 1982
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580190304
Subject(s) - chemistry , acetylene , yield (engineering) , acetic acid , acetophenone , selenium , oxidative coupling of methane , medicinal chemistry , nuclear chemistry , organic chemistry , catalysis , materials science , metallurgy
Phenyl [1‐ 14 C] acetylene (0.012mCi/mmole) was synthesized in 12.5% yield from [1‐ 14 C] acetic acid through [1‐ 14 C] acetophenone, its semicarbazone, and 4‐phenyl‐[4‐ 14 C] 1,2,3‐selenadiazole obtained by selenium dioxide oxidation. Oxidative coupling gave 1,4‐diphenyl [1,4‐ 14 C 2 ] butadiyne in 80% yield.