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A synthesis of [ 14 C] progabide®‐ a new anticonvulsant
Author(s) -
Allen J.,
Giffard D.
Publication year - 1982
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580190216
Subject(s) - chemistry , potassium carbonate , anticonvulsant , potassium cyanide , cyanide , methylene , carbon 14 , chemical synthesis , stereochemistry , radiochemistry , medicinal chemistry , organic chemistry , biochemistry , epilepsy , quantum mechanics , neuroscience , biology , in vitro , physics
Progabide®, 4‐[[(4‐chlorophenyl) (5‐fluoro‐2‐hydroxyphenyl)‐methylene]amino] butanamide, labelled individually with carbon‐14 in the butanamide side‐chain and in the imino carbon were synthesised for pharmacokinetic and metabolism studies. The former from potassium [ 14 C] cyanide and the latter from barium [ 14 C] carbonate in overall radiochemical yields of 33.8 and 42.2 % respectively.