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Preparation of methadone and some congeners labeled with tritium in the aromatic rings
Author(s) -
Kepler J. A.,
Sparacino C. M.,
Howe C. R.,
Austin R. D.
Publication year - 1982
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580190213
Subject(s) - chemistry , tritium , methadone , halogenation , tritium illumination , medicinal chemistry , radiochemistry , organic chemistry , pharmacology , medicine , physics , nuclear physics
[diphenyl‐2,2′‐ 3 H 2 ]Methadone with specific activity of 8‐30 Ci/mmol was prepared by reductive dehalogenation of 6‐dimethylamino‐4, 4‐bis(2‐chlorophenyl)‐3‐heptanone with carrier‐free tritium gas. The labeled congeners (−)‐α‐acetylmethadol, (−)‐α‐acetyl‐N‐normethadol, and (−)‐α‐acetyl‐N,N‐dinormethadol were prepared from (+)‐[diphenyl‐2,2′‐ 3 H 2 ]methadone.