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Radiation stability of angiotensin II‐amide and of its tritiated derivatives
Author(s) -
Kopoldová J.,
Hrnčíř Š.,
Mezö I.
Publication year - 1982
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580190211
Subject(s) - chemistry , amide , radiolysis , angiotensin ii , peptide , tritium , radiochemistry , irradiation , aqueous solution , biochemistry , organic chemistry , receptor , physics , nuclear physics
The gamma‐radiolysis of aqueous solutions of the peptide hormone angiotensin II‐amide and the beta‐autoradiolysis of its tritiated preparations were studied. The radiation loss and the decrease of biological activity of angiotensin II‐amide was evaluated. The main fractions of radiation products were separated and compared with the products formed during the storage of tritiated angiotensin II‐amide. The principal radiation processes taking place during the irradiation of angiotensin II‐amide were discussed.