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Tritium labelling of psychopharmacologic agents
Author(s) -
Buchman Ouri,
Shimoni Michael
Publication year - 1982
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580190117
Subject(s) - halogenation , chemistry , labelling , phenothiazine , tritium , catalysis , combinatorial chemistry , specific activity , organic chemistry , radiochemistry , pharmacology , biochemistry , medicine , physics , nuclear physics , enzyme
Attempts to reach phenothiazine derivatives labelled with tritium at high specific activity, are described. All the syntheses are based on catalysed dehalogenation procedures. The most encouraging results are those obtained by halogenation of the desired compound followed by catalytic dehalogenation with Pd/C. The specific activities are in the range of 10,000‐40,000 mCi/mmol.