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The synthesis of [ ring ‐U‐ 14 C] DDD from [ ring ‐U‐ 14 C] DDT using rat liver homogenate
Author(s) -
Fawcett S. C.,
King L. J.,
Stanley P. I.,
Bunyan P. J.
Publication year - 1981
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580181112
Subject(s) - chemistry , ring (chemistry) , yield (engineering) , incubation , radiochemistry , medicinal chemistry , stereochemistry , organic chemistry , biochemistry , materials science , metallurgy
1,1‐Di[ ring ‐U‐ 14 C] (4‐chlorophenyl)‐2,2‐dichloroethane ([ 14 C] DDD) was prepared by the anaerobic incubation of 1,1‐di[ ring ‐U‐ 14 C] (4‐chlorophenyl)‐2,2,2‐trichloroethane ([ 14 C] DDT) with homogenised rat liver in buffer. This gave a good yield of DDD which was purified chromatographically. The overall recovery of 99.5% pure DDD was 68%.