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Synthesis of deuterium labelled trifluoperazine
Author(s) -
Shetty H. U.,
Hawes E. M.,
Midha K. K.
Publication year - 1981
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580181109
Subject(s) - chemistry , trifluoperazine , deuterium , amide , radiochemistry , lithium (medication) , nuclear chemistry , organic chemistry , nuclear physics , medicine , physics , calmodulin , calcium , endocrinology
Procedures for the preparation of trifluoperazine with two, four and six deuterium atoms are described. Deuterium was introduced in the propylpiperazine side chain by treatment of the appropriate amide with lithium aluminium deuteride. The isotopic purity of the products was greater than 96.2%.