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A convenient synthesis of nitrogen‐15 and deuterium labelled octahydro‐1,3,5,7‐tetranitro‐1,3,5,7‐tetrazocine (HMX)
Author(s) -
Coburn M. D.,
Ott D. G.
Publication year - 1981
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580181005
Subject(s) - chemistry , hexamethylenetetramine , acetic anhydride , deuterium , formaldehyde , ammonia , nitrogen , organic chemistry , radiochemistry , nuclear chemistry , catalysis , physics , quantum mechanics
The preparation of pure octahydro‐1,3,5,7‐tetranitro‐1,3,5,7‐tetrazocine (HMX) labelled with nitrogen‐15 and deuterium was accomplished by sequential nitrolysis of appropriately labelled octahydro‐1,5‐diacetyl‐3,7‐endomethylene‐1,3,5,7‐tetrazocine. The latter compounds were obtained from the reaction of acetic anhydride with hexamethylenetetramine that was specifically labelled by the reaction of the appropriate formaldehyde and ammonia.