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Synthesis of carbon‐14 and deuterium labeled N‐nitroso‐2(3′,7′‐dimethyl‐2′,6′‐octadienyl)aminoethanols
Author(s) -
Abidi S. L.,
Fish U. S.,
Service Wildlife,
Idelson A. L.
Publication year - 1981
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580180817
Subject(s) - chemistry , ethanolamine , nitroso , nitrosation , nitroso compounds , alkylation , deuterium , nitrous acid , organic chemistry , medicinal chemistry , catalysis , physics , quantum mechanics
Methods of preparation of carbon‐14 and deuterium labeled N‐nitroso‐2(3′,7′‐dimethyl‐2′,6′‐octadienyl)aminoethanols are described. The primary synthetic method involved alkylation of ethanolamine or ethylglycine with suitable chlorides and subsequent mild nitrosation. Isomeric 14 C‐nitrosamines were also prepared by selective α‐cleavage of the di‐substituted ethanolamine with nitrous acid.