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A convenient synthesis of carbon labeled adenine nucleotides: Adenosine‐2‐ 13 C 5′ ‐phosphate
Author(s) -
Meyer Rich B.,
Wong Corinne G.
Publication year - 1981
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580180806
Subject(s) - chemistry , phosphate , nucleotide , adenosine , base (topology) , catalysis , condensation , palladium , stereochemistry , organic chemistry , medicinal chemistry , biochemistry , physics , thermodynamics , mathematical analysis , mathematics , gene
Treatment of adenosine 5′‐phosphate 1‐oxide with base gave 5‐amino‐1‐β‐ D ‐ribofuranosylimidazole‐4‐carboxamidoxime 5′‐ phosphate. Catalytic reduction of this amidoxime gave the versatile intermediate, 5‐amino‐1‐β‐ D ‐ribofuranosylimidazole‐ 4‐carboxamidine 5′‐phosphate. Condensation of this nucleo‐ tide with formaldehyde‐ 13 C in the presence of palladium provided a simple preparation of adenosine‐2‐ 13 C 5′‐phosphate.