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A simple synthesis of L‐[ 35 S]cysteine sulfinic acid
Author(s) -
Spears Ronald M.,
Martin David L.
Publication year - 1981
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580180717
Subject(s) - sulfinic acid , chemistry , cystine , cysteine , ammonium hydroxide , yield (engineering) , amino acid , ammonium , organic chemistry , biochemistry , materials science , metallurgy , enzyme
The synthesis of L‐[ 35 S]cysteine sulfinic acid (L‐2‐amino‐3‐[ 35 S] sulfino‐propanoic acid) in 65% yield from S‐[ 35 S]cystine is described. The procedure was designed for use with milligram quantities of starting material and requires no purification of intermediates. L‐[ 35 S]Cystine was converted first to its thiosulfonate. Subsequent reaction of the thiosulfonate with ammonium hydroxide generated L‐[ 35 S]cysteine sulfinic acid and L‐[ 35 S]cystine as the major products. The L‐[ 35 S]cystine was recovered and reprocessed thereby increasing the yield.