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No‐carrier‐added bromination of estrogens with chloramine‐t and Na 77 Br
Author(s) -
Mazaitis J. K.,
Francis B. E.,
Eckelman W. C.,
Gibson R. E.,
Reba R. C.,
Barnes J. W.,
Bentley G. E.,
Grant P. M.,
O'Brien H. A.
Publication year - 1981
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580180714
Subject(s) - halogenation , chemistry , chloramine t , chloramine , organic chemistry , combinatorial chemistry , chromatography , chlorine
The syntheses of monobromohexestrol and 17α‐bromoethynylestradiol are described as examples of bromination of phenolic and ethynyl moieties using Chloramine‐T. This technique represents a unique method of producing no‐carrier‐added radiobromoethynylderivatives. However, more efficient chromatography is needed to separate the chloroderivative, which is a side product of the reaction, from the radio‐bromoderivative.