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Biosynthetic methods for incorporating positron‐emitting radionuclides into compounds of biomedical interest
Author(s) -
Gelbard Alan S.
Publication year - 1981
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580180703
Subject(s) - chemistry , positron , radiochemistry , radionuclide , enzyme , chemical synthesis , combinatorial chemistry , biochemistry , in vitro , physics , electron , quantum mechanics
The progress that has been made in incorporating the short‐lived, positron‐emitting isotopes N‐13 and C‐11, into biologically active compounds by biosynthetic means is reviewed. These methods include the use of whole cells or plant leaves to carry out a sequence of metabolic reactions, such as nitrogen fixation or photosynthesis, and the use of purified enzymes to catalyze specific chemical reactions, to form the labeled compounds.