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Synthesis of [8‐ 3 H]Pentostatin
Author(s) -
Putt Sterling R.,
Hartman Jon D.,
Showalter H. D. Hollis,
Kepler John A.,
Taylor George
Publication year - 1981
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580180702
Subject(s) - chemistry , yield (engineering) , diastereomer , pentostatin , chromatography , high performance liquid chromatography , stereochemistry , organic chemistry , enzyme , materials science , metallurgy , adenosine deaminase
Starting from 3‐(2‐deoxy‐β‐D‐ erythro ‐pentofuranosyl)‐6,7‐dihydroimidazo[4,5‐d][1,3]diazepin‐8(3 H )‐one ( 4 ), the synthesis of both the R‐and S‐isomers of [8‐ 3 H]pentostatin has been achieved. The separation of the desired R‐isomer in Ca . 24% overall chemical yield from the R, S‐mixture was effected by preparative reverse‐phase chromatography utilizing a C18 stationary support. Crystalline product of high specific activity (227 mCi/mmole) was obtained.