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The synthesis of [2‐ 3 H 2 ] taurine and [2‐ 3 H 2 ] hypotarine
Author(s) -
Fellman J. H.
Publication year - 1981
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580180520
Subject(s) - taurine , hypotaurine , chemistry , tritium , zinc , chloride , medicinal chemistry , nuclear chemistry , inorganic chemistry , organic chemistry , amino acid , biochemistry , physics , nuclear physics
The synthesis of [2‐ 3 H 2 ]‐2‐aminoethanesulfonate [2‐ 3 H]‐taurine by the reduction of cyanomethanesulfonic acid with tritium gas is described. The conversion of [2‐ 3 H]‐taurine and its 14 C and 35 S isotopic forms to 2‐aminoethanesulfinate (hypotaurine) was accomplished by converting taurine to its corresponding sulfonyl chloride and reducing the latter with metallic zinc.