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Synthesis of 14 C‐labelled isophosphamide
Author(s) -
van Maanen J. M. S.,
Griggs L. J.,
Jarman M.
Publication year - 1981
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580180312
Subject(s) - chemistry , aziridine , phosphorus , nitrogen , radiochemistry , phosphorus 32 , medicinal chemistry , oxide , organic chemistry , nuclear chemistry , ring (chemistry) , biochemistry , nucleotide , gene
Abstract Isophosphamide labelled with 14 C in the chloroethyl group attached to the exocyclic nitrogen has been synthesised by treatment of N‐3‐hydroxypropyl‐aziridine with phosphorus oxychloride and reaction of the resulting 2‐chloro‐3‐(2‐chloroethyl) tetrahydro‐2H‐1,3,2‐oxazaphosphorine‐2‐oxide with [1‐ 14 c]‐2‐chloroethylamine.