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Synthesis Of [11β‐ 3 H]prostacyclin
Author(s) -
Blair Ian A.,
Hensby Christopher N.,
Macdermot John
Publication year - 1981
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580180310
Subject(s) - chemistry , prostacyclin , prostaglandin , cyclase , adenylate kinase , prostaglandin e , stereochemistry , biochemistry , enzyme
The synthesis of [11β‐ 3 H]prostacyclin and [11β‐ 3 H]6‐oxo‐prostaglandin F 1α has been described. The strategy involved borotritide reduction of prostaglandin D 2 , followed by cyclic iodoether formation. Adenylate cyclase activation in a neuronal somatic cell hybrid and GC‐MS were used for the analysis of the target compounds. The ready acid catalysed ketal formation of [11β‐ 3 H]6‐oxo‐prostaglandin F 1α is noted.