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The synthesis of pyrrole derivatives labelled with 13 C in selected positions: Improved procedures
Author(s) -
D'alessandro Giuliana.,
Sleiter Giancarlo
Publication year - 1980
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580170608
Subject(s) - ethyl acetoacetate , chemistry , pyrrole , ethyl acetate , ethyl ester , transformation (genetics) , organic chemistry , catalysis , biochemistry , gene
Starting from sodium acetate‐ 1 ‐ 13 C or ‐ 2 ‐ 13 C improved procedures for the preparation of ethyl acetoacetate‐ 2 , 4 ‐ 13 C 2 , ethyl acetoacetate‐ 1 , 3 ‐ 13 C 2 , ethyl acetoacetate‐ 2 ‐ 13 C , and ethyl acetoacetate‐ 2 , 3 ‐ 13 C 2 are described. A method was also worked out which allows, using the labelled ethyl acetoacetates, to obtain Knorr's pyrrole (diethyl 3 , 5 ‐dimethyl pyrrole‐ 2 , 4 ‐dicarboxylate) carrying the label in well‐defined positions in excellent yields. An example is given of further transformation of Knorr's pyrrole.