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Synthesis of trans‐[13,14‐ 14 C 2 ]‐retinoic acid
Author(s) -
Kaegi Heinz,
Chew Edward,
Chien PingLu
Publication year - 1980
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580170518
Subject(s) - chemistry , retinoic acid , amide , ether , potassium , condensation , stereochemistry , organic chemistry , biochemistry , physics , gene , thermodynamics
Trans‐[13,14‐ 14 C 2 ]‐Retinoic acid has been synthesized by condensation of β‐ionylideneacetaldehyde and 14 C‐labeled methyl senecioate in the presence of potassium amide in ether. A convenient synthesis of the key intermediate, methyl (diethoxyphosphinyl)‐[2‐ 14 C]acetate, is also described.