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Synthesis of double 15 N‐labeled nitramines: N‐nitropiperidine and N‐nitrodimethylamine
Author(s) -
Bulusu S.,
Autera J.,
Axenrod T.
Publication year - 1980
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580170514
Subject(s) - chemistry , dimethylamine , piperidine , cyclopentanone , azide , ring (chemistry) , hydride , stereochemistry , medicinal chemistry , organic chemistry , hydrogen , catalysis
Double 15 N‐labeled N‐nitropiperidine and N‐nitrodimethylamine have been conveniently prepared by oxidation of the corresponding nitrosamines. Dimethylamine‐ 15 N was commercially available while the required piperidine‐ 15 N was synthesized from cyclopentanone via the Schmidt ring‐expansion procedure using potassium azide‐1‐ 15 N, followed by hydride reduction of the resulting 2‐piperidinone‐ 15 N.