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Synthesis of six specifically deuterted indoles of biological interest
Author(s) -
Hesselgren Torbjörn,
Beck Olof
Publication year - 1980
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580170312
Subject(s) - tryptamine , chemistry , indole test , deuterium , lithium (medication) , stereochemistry , organic chemistry , medicinal chemistry , biochemistry , medicine , physics , quantum mechanics , endocrinology
Procedures for the preparation of N‐methyl‐(α,α,ß,ß‐ 2 H 4 )tryptamine, 5‐methoxy‐N‐methyl‐(α,α,ß,ß‐ 2 H 4 )tryptamine, 5‐hydroxy‐N‐methYl‐(α,α,ß,ß‐ 2 H 4 )tryptamine, (α,α,ß,ß‐ 2 H 4 )tryptophol, 5‐methoxy‐(α,α,ß,ß‐ 2 H 4 )tryptophol and 5‐hydroxy‐(α,α,ß,ß‐ 2 H 4 )tryptophol are described. Deuterium was introduced by treatment with lithium aluminium deuteride of the appropriate indole‐3‐(N‐methylglyoxylamide) or ethyl indole‐3‐glyoxalate. The isotopic purity of the products was greater than 97.3%.