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Synthesis of [17α, 16α] oxazolino steroids specifically labelled in C‐2′ of the oxazoline ring with 14 C
Author(s) -
Sartori Giuseppe,
Winters Giorgio
Publication year - 1980
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580170311
Subject(s) - chemistry , labelling , acetic anhydride , oxazoline , ring (chemistry) , deuterium , tritium , stereochemistry , organic chemistry , biochemistry , physics , quantum mechanics , nuclear physics , catalysis
The preparation of 14 C‐labelled 11β, 21‐dihydroxy‐3,20‐dioxy‐pregna‐1,4‐dieno[ 17α, 16α‐d]‐2′‐methyloxazoline‐21‐acetate and of 9α‐fluoro‐11β,21‐dihydroxy‐3,20‐dioxopregna‐l,4‐dieno[ 17α,16α ]‐2′‐methyloxazoline‐21‐acetatel Note that [17α., 160α‐d] does not refer to deuterium labelling is described. Specific labelling at the C‐2′ position was achieved reacting the corresponding 17α‐amino‐16α‐alcohols with [1‐ 14 C]‐acetic anhydride.