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Synthesis of deuterated and tritiated apogossypol
Author(s) -
Powers Larry J.,
Dorsett Preston H.
Publication year - 1980
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580170219
Subject(s) - chemistry , tritium , deuterium , sodium hydroxide , tritiated water , radiochemistry , oxide , base (topology) , sodium , nuclear chemistry , organic chemistry , physics , mathematics , nuclear physics , quantum mechanics , mathematical analysis
Apogossypol with deuterium or tritium in the 8 and 8′ positions can be synthesized by the base catalyzed deformylation of gossypol. The position of the labeling is established by the pmr spectrum of the material derived from the reaction of deuterium oxide and sodium deuteroxide. The specific activity of the tritiated material prepared from tritium oxide and sodium hydroxide is 110m Ci/m Mole. The methods described are also useful for the synthesis and storage of small quantities of unlabeled apogossypol.