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Synthese Du Tertiobutyl‐2 dinitro‐4,6 Phenol Noyau‐ 14 C (U) (“Dinoterbe” Noyau‐ 14 C)
Author(s) -
Noel JeanPierre,
Pichat Louis,
Benakis Achille
Publication year - 1980
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580170208
Subject(s) - chemistry , phenol , yield (engineering) , ring (chemistry) , high performance liquid chromatography , mass spectrum , medicinal chemistry , chromatography , nuclear chemistry , organic chemistry , mass spectrometry , materials science , metallurgy
(U‐ 14 C) Phenol and isobutene under pressure in presence of aluminium phenoxide gave in 60 % yield a mixture of (ring U‐ 14 C) 2‐t‐butylphenol (50 %) and (ring U‐ 14 C)‐2,6‐di‐t‐butylphenol (10 %) which were separated by column chromatography on silicagel. Each t‐butylphenol was nitrated under appropriate conditions to give an 35 % overall yield of (ring‐U‐ 14 C)‐4,6‐dinitro‐2‐t‐butylphenol : specific activity : 27.4 mCi/mMol which was proved by TLC and HPLC to be 99 % radiochemically pure.