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Radioactively labelled epoxides part II. (1) tritium labelled cyclohexene oxide, transstilbene oxide and phenanthrene 9,10‐oxide
Author(s) -
Oesch Franz,
Sparrow Alan J.,
Platt Karl L.
Publication year - 1980
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580170110
Subject(s) - chemistry , cyclohexene oxide , oxide , epoxide , phenanthrene , tritium , yield (engineering) , cyclohexene , radiochemistry , ketone , organic chemistry , nuclear chemistry , catalysis , physics , materials science , nuclear physics , metallurgy
Tritium labelled cyclohexene oxide, trans‐stilbene oxide and phenanthrene 9,10‐oxide were prepared with specific activities of 0.7 ‐ 1.1 mCi per mmole starting with monoor diketo compounds. Tritium was introduced by reducing the ketone precursors with tritiated complex metal hydrides. The resulting alcohols were transformed to the epoxides by methods described for the unlabelled compounds. The syntheses require only two or three steps and yield cyclohexene oxide, trans‐stilbene oxide and phenanthrene 9,10‐oxide, important substrates for the study of epoxide hydratase and glutathione S‐transferases in high radiochemical purity.