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Preparation of a radiobrominated fluorescein for liver scanning
Author(s) -
Gobuty Allan H.,
Spicer Jay A.,
Dressler Robert L.
Publication year - 1980
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580170108
Subject(s) - chemistry , resorcinol , chromatography , yield (engineering) , mass spectrometry , thin layer chromatography , column chromatography , fluorescein , organic chemistry , fluorescence , quantum mechanics , metallurgy , materials science , physics
A radiobrominated compound, 4,5,6,7‐tetrachloro‐2′,4′,5′,7′‐tetrabromofluorescein‐ 77 Br 4 was prepared from resorcinol, tetrachlorophthallic anhydride and Na 77 Br by a two‐step synthesis. The precursor was identified by spectrometry. Final purification utilized column chromatography. The product was identified by thin layer chromatography and spectrometry. The yield was 60% of theoretical.