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Derivate von [ 103 Ru]‐methyl‐ruthenocen Konstitution und Organ‐verteilung von Potentiellen Radiopharmaka
Author(s) -
Schneider Michael,
Wenzel Martin
Publication year - 1980
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580170102
Subject(s) - chemistry , conjugate , benzoic acid , aldehyde , medicinal chemistry , stereochemistry , organic chemistry , catalysis , mathematical analysis , mathematics
Synthesis and organ distribution of the oxidation products of methylruthenocene up to ruthenocene acid and of various derivatives of hydroxymethylruthenocene labelled with 103 Ru are described. Hydroxymethylruthenocene and ruthenocenecarboxaldehyde show like ruthenocene acid a comparable organ distribution and a high affinity to the kidneys. Probable hydroxymethylruthenocene and the aldehyde are oxidizid in vivo and then excreted as acid or as conjugate via kidneys. The benzoic acid ester of hydroxymethylruthenocene enriches in the adrenals with high contrast to kidneys. Tumor affinity of all compounds tested was low.