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A method for the preparation of 14 C‐labeled carboxylic acids. Synthesis of 6,11‐dihydro[b,e]thiepin‐11‐one‐3‐yl acetic 14 C‐acid
Author(s) -
Parnes Howard
Publication year - 1979
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580160515
Subject(s) - chemistry , decarboxylation , carbonation , acetic acid , carboxylic acid , malonic acid , derivative (finance) , carbon 14 , organic chemistry , carboxylate , catalysis , physics , quantum mechanics , financial economics , economics
An example of a potentially general method for the preparation of 14 C‐carboxylic acids based on the carbonation of an α‐lithiated carboxylate is described. This procedure requires only the unlabeled analog of the desired 14 C‐acid as the precursor. The possibility of carrying out the selective decarboxylation of a malonic acid derivative with loss of only the unlabeled carboxyl group is described.