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Synthesis of 5‐ethyl‐ d 5 ‐5‐phenyl‐2‐thioxobarbituric acid, primidone‐ethyl‐ d 5 and phenobarbital‐ethyl‐ d 5
Author(s) -
Andresen Brian D.,
Biemann K.
Publication year - 1979
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580160505
Subject(s) - chemistry , primidone , ethyl ester , phenobarbital , deuterium , organic chemistry , chromatography , anticonvulsant , pharmacology , epilepsy , medicine , physics , quantum mechanics , neuroscience , biology
Three deuterium labelled drugs, 5‐ethyl‐ d 5 ‐5‐phenylthiobarbi‐turic acid, primidone‐ethyl‐ d 5 , and phenobarbital‐ethyl‐ d 5 have been prepared employinq a three step synthesis utilizing diethyl phenylmalonate and bromoethane‐ d 5 . Overall isotopic purity of the labelled drugs was in excess of 95%. Complete synthetic techniques as well as spectral data of labelled intermediate and drugs are presented.