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An efficient and convenient synthesis of 5‐(3,3‐dimethyl‐ 14 C‐1‐triazeno)‐imidazole‐4‐carboxamide
Author(s) -
Farquhar D.,
Benvenuto J. A.,
Loo Ti Li
Publication year - 1979
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580160414
Subject(s) - chemistry , carboxamide , imidazole , dimethylamine , yield (engineering) , methanol , chemical synthesis , medicinal chemistry , organic chemistry , in vitro , materials science , metallurgy , biochemistry
Reaction of dimethylamine‐ 14 C with a four‐fold molar excess of 5‐doazoimidazole‐4‐carboxamide in methanol followed by column chromatography of the product on basic alumina afforded 5‐(3,3‐dimethyl‐ 14 C‐1‐triazeno)imidazole‐4‐carboxamide in 70–75% yield and greater than 99.9% radiochemical purity. The preparation is suitable for chemical and biological mechanistic studies.