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Preparation of 3 H‐labelled apomorphine, N‐ n ‐propylnorapomorphine, and O, O‐dipivaloylapomorphine
Author(s) -
Soine William H.,
Salgo Peter,
Smith Robert V.
Publication year - 1979
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580160412
Subject(s) - chemistry , apomorphine , tritiated water , trifluoroacetic acid , tritium , deuterium , hydrogen–deuterium exchange , radiochemistry , stereochemistry , organic chemistry , hydrogen , biochemistry , receptor , physics , quantum mechanics , nuclear physics , agonist
Apomorphine and N‐ n ‐propylnorapomorphine were tritiated using trifluoroacetic acid‐ tritiated water mixtures. This provides a route to the synthesis of tritiated O,O‐dipivaloylapomorphine. Deuterium exchange and NMR studies indicate that exchange only involves protons at the C‐8 and C‐9 positions.