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Synthesis of mevalonolactone‐2,3‐ 13 C 2
Author(s) -
Degraw Joseph I.,
Uemura Ieaki
Publication year - 1979
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580160406
Subject(s) - chemistry , sodium borohydride , hydrolysis , substrate (aquarium) , stereochemistry , borohydride , mevalonic acid , organic chemistry , biosynthesis , catalysis , enzyme , oceanography , geology
The synthesis of mevalonolactone with 13 C‐labels at positions 2 and 3 is reported. Hydrolysis of methyl 3‐hydroxy‐3‐methyl‐5,5‐dimethoxy‐valerate‐2,3‐ 13 C 2 to the aldehydo acid followed by reduction with sodium borohydride yielded the title compound. The material is useful as a substrate in biosynthetic studies using 13 C‐NMR as an analytical tool.