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Preparation of the radioiodinated histamine amide of 4‐0‐(carboxypropyl)‐diethylstilbestrol
Author(s) -
Johnson Howard J.,
Cernosek Stanley F.,
GutierrezCernosek Rose Mary
Publication year - 1979
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580160317
Subject(s) - diethylstilbestrol , chemistry , chloramine t , derivative (finance) , histamine , iodine , amide , radioimmunoassay , estrogen , diazo , combinatorial chemistry , organic chemistry , hormone , medicine , biochemistry , financial economics , economics
The mixed anhydride synthesis provides a route to an iodinated form of the synthetic estrogen diethylstilbestrol (DES). Labelling of histamine by the oxidative Chloramine‐T method prior to coupling to 4‐0‐(carboxypropyl)‐diethylstilbestrol ( 1 ) minimizes radiation damage to the sensitive DES derivative. The radioiodinated derivative has demonstrated binding to an anti‐DES serum, thus making possible a potentially useful iodine‐based radioimmunoassay for DES.