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Synthesis of osseous specific 32 P‐labeled disodium ethane‐1‐hydroxy‐1,1‐diphosphonate
Author(s) -
McCreary Lionel D.,
Tofe Andrew J.,
Francis Marion D.
Publication year - 1979
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580160315
Subject(s) - chemistry , radiochemistry , acetic acid , specific activity , isotope dilution , salt (chemistry) , nuclear chemistry , radionuclide , chromatography , mass spectrometry , organic chemistry , physics , quantum mechanics , enzyme
High specifie activity 32 P‐Iabeled disodium ethane‐1‐hydroxy‐1,1‐diphosphonate has been prepared for specific use as a radiotherapeutic ameliorative treatment of osseous tumors by reacting 32 P‐labeled phosphorus trichloride, acetic acid and water. This compound has been purified by crystallization of the disodium salt from a water‐ethanol solution. Product identity and purity were established by reverse isotope dilution analysis. Spectrochemical quantitation, thin layer chromatography, radionuclide beta energy and half‐life determinations are presented as essential procedures for establishing chemical and radiochemical purity when human distribution studies are planned.