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Syntheses with stable isotopes: Thymine‐2,6‐ 13 C 2
Author(s) -
Redwine Carolyn M.,
Whaley Thomas W.
Publication year - 1979
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580160211
Subject(s) - chemistry , thymine , acetic acid , yield (engineering) , aqueous solution , sodium cyanide , cyanide , urea , kinetic isotope effect , medicinal chemistry , radiochemistry , nuclear chemistry , organic chemistry , deuterium , dna , biochemistry , materials science , metallurgy , physics , quantum mechanics
A three‐step synthesis of thymlne‐2,6‐ 13 C 2 from urea‐ 13 C, sodium cyanide‐ 13 C, and α‐bromopropionic acid is described. The last reaction involves hydrogenation of α‐cyano‐ 13 C‐propionylurea‐ 13 C in aqueous acetic acid and produces thymine‐2,6‐ 13 C 2 in 50–60% yield. The mechanism of this reaction is discussed.