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Labeling with 131 I of chloroquine‐analogues for the detection of ocular melanoma
Author(s) -
Bakker Cees N. M.,
Kaspersen Frans M.
Publication year - 1978
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580150181
Subject(s) - chemistry , chloroquine , melanoma , ocular melanoma , melanoma diagnosis , pharmacology , cancer research , pathology , malaria , biology , medicine
Electrophilic iodination of chloroquine with 131 I by the chloramine‐T method results in labeled 3‐iodochloroquine (maximum yield 30%) and a number of other labeled quinolines. This method also gives 3‐chlorochloroquine in mass amounts. Higher yields (up to 60%) of labeled 3‐iodochloroquine are obtained by isotopic exchange with 131 I‐iodide as its phosphate‐salt.